I'd Scrooge McDuck that fortune.
If we had that kind of fortune I know my wife would be giving vast amounts to dog rescue organizations. I'd setup scholarships (for college, trade schools, etc) for kids that come from single parent homes. I'd put a lot of money into cancer research. I'd spend a lot of money backing actual small government political candidates. I'd do a lot of secret santa type stuff for families in need around the holidays.