NFL: I'd run a full on college offense. Tons of movement, RPOs, options, Run and Gun etc... I'd take players like Lamar Jackson/Geno Smith/RG3/Cardale Jones/Kapernick/etc... and run them into the ground. If one goes down, I'd have another QB behind him ready to take his place.
It would help with scouting, getting rookies up to speed [esp oline & WR - which both have well known challenges adjusting to NFL]. NFL is need of a change up, too many dinosaurs with bad schemes, not adjusting to talent, etc... Would be a good way to play moneyball also I'd imagine.